Our Extended Family of Portfolio Companies

Investing in transformational ideas and entrepreneurial grit to solve major unmet needs in patient care

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410 Medical is dedicated to developing innovative products that help emergency clinicians provide better care for critically ill patients.

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Aer Therapeutics is a clinical stage biopharmaceutical company developing a novel inhaled approach to treat lung disease with excess mucus and mucus plugs.

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Altis has developed a patent-pending stem cell technology recreating the human intestinal epithelium for compound screening and microbiome research.

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AN2 is a biopharmaceutical company focused on developing novel medicines. IPO in March 2022 (NASDAQ: ANTX)

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Developer of scientific data management software designed to enhance workplace collaboration and accelerate the rate of drug discovery. Acquired by PerkinElmer (NYS: PKI) in March 2011.

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AtaCor Medical is developing a novel extracardiac pacing system that does not require leads or hardware to be placed inside or onto the heart.

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Providing in-home primary care for seniors with complex conditions, especially those with dementia

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Atsena Therapeutics is a clinical-stage, ophthalmology-focused gene therapy company

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Avivomed engages in developing neuromodulation therapy intended to treat unmet clinical needs.

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Axonis Therapeutics is a Boston-based, neuro-focused biotechnology company developing first- and best-in-class medicines targeting KCC2.

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Ed-tech platform that pairs high achieving, under-resourced students with mentors to guide them to successful career outcomes

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Their clinical research software accelerates timelines by automating multiple high impact processes.

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Bivarus is a healthcare IT company that has developed an elegant and efficient patient survey platform. Acquired by Press Ganey Associates in January 2018.

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Boomerang Medical is developing a technology to advance the treatment of autoimmune diseases by using electrical nerve stimulation

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(BITT) is a Boston-based biopharmaceutical company developing immune-based approaches for the treatment of cancer and infectious diseases.

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Tech-enabled service designed to make caregiving easier for family caregivers

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Cardiosense is building a physiological waveform data platform that leverages novel multi-modal sensors and industry-leading AI

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Manufacturer of late-stage clinical biopharmaceutical products. IPO in June, 2016 (NASDAQ:CLSD).

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Clinipace is a clinical research organization whose services are enhanced by a proprietary on-demand software platform and clinical research services. Acquired by dMed in April 2021.

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Developer of an online platform for clinical payments. Acquired by BioClinica on January 19, 2016.

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Code Bio is a preclinical stage company developing novel genetic medicines.

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Contego Medical has developed a platform based on the integration of an embolic protection filter and a treatment device into one single catheter.

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Developing first-in-class approach to activate myeloid cells to kill cancer. 

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Provider of genomic and biomedical computing platform intended to empower scientists and clinicians. Acquired by Veritas Genetics in August 2017.

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CVRx has developed proprietary implantable technology for the treatment of high blood pressure and heart failure. IPO in June 2021 (NASDAQ: CVRX).

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Developer of a technology designed to extract highly sensitive nucleic acid quantification. Acquired by Bio-Rad 2021

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Provider of a clinical research platform intended to revolutionize the clinical research industry

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Developer of a system to enhance embolic cerebral protection. Acquired by Edwards Lifesciences (NYSE: EW) in March 2011.

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Endogenex is a clinical stage company, founded to improve outcomes for people living with Type 2 Diabetes.

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Developer of biologic and medical device technologies for wound management designed to improve the safety and availability of human blood supply.

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The company’s small-molecule therapies focus on cyclin-dependent kinases and CDKs. IPO in May 2017 (NASDAQ: GTHX).

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GeneCentric Therapeutics is applying proprietary technology to identify drug responder populations that enable the development of precision cancer drugs.

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GoCheck Kids is the leading digital vision screening platform for children. 

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Gozio promotes loyalty and growth for a health system by creating a system-specific app that enhances the patient experience.

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Developer of injectable controlled release technologies designed to reduce the frequency of dosing for ocular therapies. IPO in September 2020 (NASDAQ: GRAY).

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Provider of a histotripsy platform designed for the treatment of cancer. Acquired by Bezos Expeditions, Wellington K5 Global 2025

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Huma.ai is a next-generation low code/no code data science solution for the life sciences industry.

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IMMvention is developing novel, first-in-class therapies for treating hemolytic anemias.

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Engages patients and families in a personalized way to initiate discussions on end-of-life care planning. Acquired by Aledade in January 2022.

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iVEAcare is developing innovative neuromodulation therapy to treat unmet clinical needs impacting large patient populations.

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Founded by pediatricians, developing medical content in an educational format embraced by children. Acquired by Falfurrias 2024

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Kymera is developing a heterobifunctional small molecule drug platform. IPO in August 2020 (NASDAQ: KYMR).

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Developer of innovative neurodegeneration small-molecules intended to establish a platform for novel drug discovery.Acquired by Bial in October 2020.

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Provider of patient experience platform designed to facilitate the relationship between physicians and patients. Acquired by NextGen 2019

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We have developed a novel liquid biopsy assay platform which interrogates tumor-derived extracellular vesicles.

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Operator of a biopharmaceutical agency intended to offer drugs for the treatment of diabetes and other metabolic disorders.

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Developer of staffing, communication and schedule management tools designed to modernize staffing processes. Acquired by HealthStream 2020

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The Company’s lead product candidate, PB2452, is a novel reversal agent for the antiplatelet drug ticagrelor. IPO in October, 2018 (NASDAQ:PHAS)

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Perfuse Therapeutics, Inc. is a seed stage biotechnology company focusing on improving retinal perfusion

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Developer of a molecular diagnostics technology designed to dramatically reduce time to results in microbiology.

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A developer of multiple antibiotic drugs intended to combat antimicrobial resistance. Acquired by Shionogi 2023

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RapidPulse, Inc. is a privately held medical device company that develops minimally invasive vascular products for ischemic stroke.

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The SHAPE-MaP technology developed in the lab of Dr. Weeks identifies functional motifs within RNA by mapping the RNA three-dimensional structure.

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Developer of epigenetic drugs intended to be used for the treatment of cognitive disorders and diseases of the brain. Acquired by NASDAQ: ALKS in Nov 2019

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Software and logistics solution for physicians allowing them to become independent DME suppliers

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SafeRide’s technology provides end-to-end data transparency while improving patient experience, population health, and program efficiency.

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Shattuck Labs is a clinical-stage biotechnology company for the treatment of cancer and autoimmune disease. IPO in October 2020 (NASDAQ: STTK)

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Standard Bariatrics is developing a clamp and stapler to standardize sleeve gastrectomy procedures. Acquired by Teleflex in September 2022.

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Stridebio is developing engineered viral vectors for gene therapy. Acquired by Ginkgo Bioworks 2023

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Platform linking natural compounds and ethnobotanical evidence to generate novel drug candidates

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Synaptrix is focused on developing and commercializing drug-free, long-lasting solutions for post-operative pain management.

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Ten63 Therapeutics is focused on improving human health by developing better, more durable therapeutics against cancer and some of the world’s most lethal diseases.

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Developer of novel engineered compounds designed to corneal dystrophies, improve human health and create new therapies using drugs developed with protein engineering.

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Tune strives to develop paradigm-changing cell and gene therapies.

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The company’s lead drug has potential to be a game-changer in the treatment of HITT. Acquired by Cadrenal Therapeutics 2025

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Developer of therapies based on metalloenzyme chemistry and biology platform. Acquired by NovaQuest Capital Management in January 2018.

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Vigil Neuroscience is the world’s first microglia-focused therapeutics company. IPO in January 2022 (NASDAQ: VIGL).

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Provides analytics and software infrastructure to support the operations of social care networks, Medicaid waiver programs, and value-based care organizations

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Sleep management platform built to address sleep conditions from testing through ongoing care via a wearable patch

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Developer of health engagement platform intended to connect families to health resources on the smartphone.

“It is not the critic who counts: not the man who points out how the strong man stumbles or where the doer of deeds could have done better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood, who strives valiantly, who errs and comes up short again and again, because there is no effort without error or shortcoming, but who knows the great enthusiasms, the great devotions, who spends himself in a worthy cause; who, at the best, knows, in the end, the triumph of high achievement, and who, at the worst, if he fails, at least he fails while daring greatly, so that his place shall never be with those cold and timid souls who knew neither victory nor defeat.”


Theodore Roosevelt
Speech at the Sorbonne, Paris, April 23, 1910