Our Extended Family of Portfolio Companies

Investing in transformational ideas and entrepreneurial grit to solve major unmet needs in patient care

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Aer Therapeutics is a clinical-stage biopharmaceutical company developing first-in-class inhaled therapies that target mucus obstruction in chronic lung diseases.

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Altis has developed a patent-pending stem cell technology recreating the human intestinal epithelium for compound screening and microbiome research.

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AN2 Therapeutics is a clinical-stage biotech company advancing novel small molecule therapeutics.

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Atsena Therapeutics is a clinical-stage gene therapy company focused on reversing or preventing blindness from inherited retinal diseases

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Axonis Therapeutics is a clinical-stage biotechnology company developing first-in-class small molecule therapies that target KCC2

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Boston Immune Technologies & Therapeutics is a clinical-stage biotechnology company developing a novel class of antagonist antibodies

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Clearside Biomedical is a biopharmaceutical company focused on revolutionizing treatment for sight-threatening back-of-the-eye diseases. IPO in June, 2016 (NASDAQ:CLSD).

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Code Bio is a preclinical stage company developing novel genetic medicines.

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CREATE Medicines is a clinical-stage biotechnology company pioneering a new class of in vivo immune programming therapies

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G1 Therapeutics, Inc. is a commercial-stage biopharmaceutical company. IPO in May 2017 (NASDAQ: GTHX) Acquired by Pharmacosmos in 2024

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Graybug Vision, Inc. was a clinical-stage ophthalmology company developing sustained-release therapies. IPO in September 2020 (NASDAQ: GRAY).

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MMvention Therapeutix, Inc. is an early-stage biotechnology company focused on discovering and developing novel oral small-molecule therapeutics

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Kymera Therapeutics, Inc. is a clinical-stage biotechnology company pioneering targeted protein degradation. IPO in August 2020 (NASDAQ: KYMR).

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Developer of innovative neurodegeneration small-molecules intended to establish a platform for novel drug discovery.Acquired by Bial in October 2020.

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Operator of a biopharmaceutical agency intended to offer drugs for the treatment of diabetes and other metabolic disorders.

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The Company’s lead product candidate, PB2452, is a novel reversal agent for the antiplatelet drug ticagrelor. IPO in October, 2018 (NASDAQ:PHAS)

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Perfuse Therapeutics is a clinical-stage biopharmaceutical company developing first-in-class therapies to improve retinal blood flow and treat ischemia-driven eye diseases.

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Qpex Biopharma is a clinical-stage biopharmaceutical company developing novel anti-infective therapies. Acquired by Shionogi 2023

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Ribometrix is a biotechnology company pioneering a new class of small-molecule therapeutics that directly target the three-dimensional structures of RNA to modulate disease biology.

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Rodin Therapeutics was a biotechnology company focused on discovering and developing first-in-class small molecule therapeutics. Acquired by ALKS in Nov 2019

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Shattuck Labs is a clinical-stage biotechnology company advancing novel biologic medicines for inflammatory and immune-mediated diseases. IPO in October 2020 (NASDAQ: STTK)

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Stridebio is developing engineered viral vectors for gene therapy. Acquired by Ginkgo Bioworks 2023

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Sensorium Therapeutics is a clinical-stage biotechnology company developing next-generation brain and mental health medicines.

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Ten63 Therapeutics is a computational drug discovery company leveraging its proprietary AI- and physics-based platform to design novel therapeutics

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Trefoil Therapeutics is a clinical-stage biotechnology company developing regenerative therapies to restore vision for people with corneal diseases.

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Tune Therapeutics is a biotechnology innovator advancing a new class of epi-therapeutic medicines

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Viamet Pharmaceuticals is a biotechnology company. Acquired by NovaQuest Capital Management in January 2018.

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Vigil Neuroscience is a clinical-stage biotechnology company. IPO in January 2022 (NASDAQ: VIGL). Acquired by Sanofi in 2025.

“It is not the critic who counts: not the man who points out how the strong man stumbles or where the doer of deeds could have done better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood, who strives valiantly, who errs and comes up short again and again, because there is no effort without error or shortcoming, but who knows the great enthusiasms, the great devotions, who spends himself in a worthy cause; who, at the best, knows, in the end, the triumph of high achievement, and who, at the worst, if he fails, at least he fails while daring greatly, so that his place shall never be with those cold and timid souls who knew neither victory nor defeat.”


Theodore Roosevelt
Speech at the Sorbonne, Paris, April 23, 1910